For three decades, mean-variance analysis has served as the standard procedure for constructing portfolios. Recently, investors have experimented with a new optimization procedure, called full-scale optimization, to address certain limitations of mean-variance optimization. Specifically, mean-variance optimization assumes that returns are normally distributed or that investor preferences are well approximated by mean and variance. Full-scale optimization relies on sophisticated search algorithms to identify the optimal portfolio given any set of return distributions and based on any description of investor preferences. Full-scale optimization yields the truly optimal portfolio in sample, whereas the mean-variance solution is an approximation to the insample truth.